Prohibited in cosmetics (EU)
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A UV photoinitiator used in gel nails — but newly classified a reproductive toxin. EU cosmetics ban took effect in 2025; avoid going forward.
Trimethylbenzoyl diphenylphosphine oxide (TPO, CAS 75980-60-8) is a photoinitiator used in UV-cured gel nail polish and artificial-nail products. In 2023 the EU SCCS concluded it is a CMR Category 1B substance (reproductive toxicant) and in Commission Regulation (EU) 2024/197 it was added to Annex II, prohibiting its use in cosmetic products across the EU from September 2025. ACD to TPO in gel-nail users and technicians is extensively documented in dermatology literature. Use going forward is non-compliant in the EU; reformulation to alternative photoinitiators (TPO-L, BAPO variants) is underway industry-wide.
Function
Skin benefits
- Effective UV photoinitiator in gel nail products (functional benefit, not cosmetic skin benefit)
Known concerns
- EU SCCS: classified CMR Cat. 1B (reproductive toxicity)
- EU Regulation 2024/197: prohibited in cosmetic products from September 2025
- Documented allergic contact dermatitis in gel-nail users
- Occupational sensitiser for nail technicians
- Migrates out of poorly cured gel
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.