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TRIS-HYDROXYMETHYLNITROMETHANE

CAS 126-11-4
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Tris-hydroxymethylnitromethane is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Tris-hydroxymethylnitromethane (CAS 126-11-4) is an organic nitro compound used as a preservative and antibacterial agent in cosmetic formulations. GHS hazard statements include H302 (harmful if swallowed), H315 (skin irritation), H319 (eye irritation), H332 (harmful if inhaled), H335 (respiratory irritation), H400 (very toxic to aquatic life), H410 (very toxic to aquatic life with long-lasting effects). EU CosIng indicates it is restricted under Annex III; concentration limits apply for leave-on skin products. Not permitted in leave-on products intended for mucous membranes. Skin sensitization is a documented concern.

Skin benefits

  • Preservative function extends product shelf life

Known concerns

  • Skin sensitization and irritation
  • Aquatic toxicity (H400, H410)
  • Respiratory irritation if inhaled
  • Not for mucous membrane use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.