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Tritolyl phosphate

CAS 1330-78-5
26

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An organophosphate plasticizer with structural alerts for neurotoxicity and reproductive toxicity, not approved for cosmetic use in the EU.

Tritolyl Phosphate is an organophosphate ester where the aryl groups are tolyl (methylphenyl) substituents. Like other aryl phosphate plasticizers (such as triphenyl phosphate or tricresyl phosphate), it has raised concerns for neurotoxicity (organophosphate-induced delayed neurotoxicity - OPIDN) and reproductive effects. It is classified as a Category 2 reproductive toxicant and is on EU SVHC (Substances of Very High Concern) candidate list for its PBT (persistent, bioaccumulative, toxic) properties.

Known concerns

  • Category 2 reproductive toxicant
  • SVHC (Substance of Very High Concern) - PBT properties
  • Neurotoxicity concern from organophosphate structure
  • Aquatic toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.