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Antimicrobial

TROPOLONE

CAS 533-75-5
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A naturally occurring aromatic compound with antimicrobial and tyrosinase-inhibiting activity. Promising in research but its strong metal-chelation and cytotoxicity profile keep it out of mainstream cosmetic preservatives.

Skin benefits

  • Inhibits tyrosinase (potential brightening)
  • Broad antimicrobial activity
  • Antioxidant in vitro

Known concerns

  • Cytotoxic above low %
  • Strong copper/iron chelator — can disturb enzymes
  • Not on EU Annex V approved preservatives list
  • Sparse human safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.