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Non-cosmetic (biogenic amine)

TYRAMINE HCL

CAS 60-19-5
50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A biogenic amine mostly known from food chemistry — not a standard cosmetic ingredient. Pharmacologically active and under-characterized topically.

Tyramine HCl (CAS 60-19-5) is the hydrochloride of tyramine, a monoamine derived from the amino acid tyrosine. In physiology it is a vasoactive amine implicated in blood pressure regulation and the well-known "cheese reaction" with MAO inhibitors; dermal absorption data are limited but topical tingling or flushing can occur. It is not a standard cosmetic ingredient — EU CosIng does not list a cosmetic function, and formal CIR/SCCS reviews are absent. Appearances in cosmetic databases are typically research/chemistry artifacts rather than commercial formulation use. Scored orange because it is pharmacologically active and under-characterized in topical use, not because of proven harm at cosmetic exposure.

Skin benefits

  • Claimed signaling effects — unverified
  • Research-stage ingredient

Known concerns

  • Pharmacologically active amine
  • No cosmetic regulatory standing
  • Possible topical tingling/flushing
  • Under-characterized for cosmetic safety

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.