Xylometazoline (INN) and its salts
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Xylometazoline (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.
Xylometazoline is an alpha-adrenergic agonist used as a topical nasal decongestant. Its inclusion in EU Annex III (restricted substances) at concentrations >=0.1% reflects concerns about its sympathomimetic pharmacological activity. While permitted at lower concentrations in some cosmetic contexts, the regulatory threshold is set to prevent pharmacological effects that would classify the product differently from conventional cosmetics.
Known concerns
- EU Annex III restricted at >=0.1%
- Pharmacologically active sympathomimetic
- Potential for vasoconstrictive effects
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.