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Banned Substance

Yohimbine and its salts

CAS 146-48-5
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Yohimbine is a pharmacologically active indole alkaloid (alpha-2 adrenergic antagonist) listed on EU Cosmetics Regulation Annex II as prohibited. It is a drug, not a cosmetic ingredient, with cardiovascular risk on systemic exposure.

Skin benefits

  • No cosmetic skin benefit

Known concerns

  • EU Annex II prohibited
  • Adrenergic pharmacology
  • Cardiovascular and CNS effects
  • No safe cosmetic level established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.