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Hair dye intermediate

2,4,5,6-Tetraaminopyrimidine sulphate

CAS 5392-28-9
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

2,4,5,6-Tetraaminopyrimidine sulphate is a regulated oxidative hair dye coupler. SCCS reviewed it as safe up to 3.4 percent in hair dyes, with class-typical sensitization caveats common to aromatic amine dyes.

Function

HAIR DYEING

Skin benefits

  • Approved oxidative hair dye coupler that contributes to grey-coverage shades
  • SCCS has reviewed its use and considers it safe in eyelash dye formulations at tested concentrations
  • Permitted in hair dye formulations at up to 3.4 percent under Annex III of EU Cosmetics Regulation

Known concerns

  • Aromatic amine class is associated with skin sensitization and allergic contact dermatitis
  • Use restricted to professional or carefully formulated products with strict concentration limits
  • Potential for nitrosamine formation when combined with nitrosating co-ingredients

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.