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Hair dye intermediate

5-AMINO-2,6-DIMETHOXY-3-HYDROXYPYRIDINE

CAS 104333-03-1
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An aminohydroxy-methoxypyridine used as a coupler in oxidative hair dyes. As an aromatic amine intermediate it carries class-typical sensitization risk, with limited SCCS safety data specific to it.

Skin benefits

  • Used as a coupler intermediate in oxidative permanent hair dyes for nuanced shade development
  • Allows formulators to fine-tune cool brown and ash tones in combination with primary dye precursors

Known concerns

  • Aromatic amine hair dye intermediate; class is associated with skin sensitization and allergic contact dermatitis
  • SCCS opinion data specific to this exact molecule is sparse and not yet definitive on safe-use levels
  • Potential for nitrosamine formation if formulated alongside nitrosating agents in the same product

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related hair dye intermediates

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.