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2,6-DIMETHYL-P-PHENYLENEDIAMINE HCL

CAS 56496-89-0
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dimethyl-P-Phenylenediamine Hcl is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

2,6-Dimethyl-p-phenylenediamine HCl (also called 2,6-dimethyl-1,4-phenylenediamine dihydrochloride) carries the GHS Warning signal word with H302 (harmful if swallowed), H312 (harmful in contact with skin), H315 (skin irritation), H319 (serious eye irritation), H332 (harmful if inhaled), and H335 (respiratory irritation). This toluene-2,4-diamine analog is an aromatic amine hair dye intermediate regulated under EU Annex III provisions. The SCCS has recommended strict concentration limits for toluene-derived phenylenediamines and has noted concerns about ortho-substitution patterns modifying toxicity profiles.

Skin benefits

  • Functions as a primary intermediate in oxidative hair coloration
  • Enables grey coverage and tonal development

Known concerns

  • Acute oral toxicity (H302)
  • Dermal toxicity (H312)
  • Eye, skin and respiratory irritation (H315/H319/H332/H335)
  • EU regulatory attention as a toluene-derived aromatic diamine
  • Potential for aromatic amine oxidation and sensitizing metabolite formation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.