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(3-Chloro-2-hydroxypropyl) trimethylammonium chloride

CAS 3327-22-8
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

This quaternary ammonium compound is primarily used in industrial water treatment and textile processing, carrying concerns about potential carcinogenicity and environmental aquatic toxicity.

(3-Chloro-2-hydroxypropyl) trimethylammonium chloride (CHPTAC) is a quaternary ammonium salt with a chlorinated hydroxypropyl group. It is classified as H351 (suspected of causing cancer) under CLP regulation. The compound is primarily used as an intermediate in the production of cationic starch for paper and textile industries and cationic polymers for water treatment. It is not listed in EU cosmetics regulation Annexes, effectively prohibiting cosmetic use. Its quaternary ammonium structure raises concerns about persistence and potential endocrine-disrupting properties, while the epoxide-forming potential in certain conditions adds to its hazard profile.

Known concerns

  • Suspected carcinogen (H351)
  • No EU cosmetic approval
  • Potential epoxide formation
  • Environmental aquatic toxicity
  • Persistence concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.