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2-Methyl-1-(4-methylthiophenyl)-2-morpholino-propan 1-one

CAS 71868-10-5
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A morpholine-based photoinitiator used in UV-curable nail gels and coatings, it can cause photoallergic contact dermatitis and is restricted to non-skin-contact industrial cosmetic applications in some EU member states.

This morpholino-propanone functions as a photoinitiator (Type I) in UV/LED-curable resin systems such as nail gels and hybrid coatings. Photoinitiators are known to cause photoallergic contact dermatitis in susceptible individuals, and specific derivatives (including aryl morpholinyl ketones) have faced regulatory scrutiny in the EU under the Cosmetics Regulation. While not currently listed in a specific EU Annex restriction, the Committee for Risk Assessment (RAC) has flagged photoinitiators in general as requiring better sensitisation data. Concentration in finished nail products is typically very low due to polymerisation conversion.

Known concerns

  • Photoallergic contact dermatitis risk — documented photoinitiator concern
  • Not fully assessed under EU Regulation 1223/2009 for skin-contact products
  • Residual monomer concerns in poorly cured nail gel formulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.