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2-NITRO-P-PHENYLENEDIAMINE

CAS 5307-14-2
32

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-substituted hair dye intermediate restricted under EU Annex II due to carcinogenic potential of its aromatic amine.

Listed under EU Annex II/1319 restriction, 2-Nitro-p-phenylenediamine is prohibited in cosmetic products due to carcinogenic concern from the p-phenylenediamine backbone. The nitro group reduction in vivo can yield mutagenic intermediates, making it unsuitable for any cosmetic application in the EU market.

Known concerns

  • EU Annex II/1319 banned substance
  • Carcinogenic concern from p-phenylenediamine moiety
  • Potential in vivo reduction to mutagenic intermediates
  • Prohibited regardless of concentration

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.