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4-Hydroxy- 3-methoxybenz- aldehyde

CAS 121-33-5
63

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

4-hydroxy- 3-methoxybenz- Aldehyde is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a widely used aromatic compound providing vanilla-like scent and flavor. The EU Cosmetics Regulation (EC) No 1223/2009 requires its declaration in the ingredient list when present above 0.001% in leave-on or 0.01% in rinse-off products, as it is recognized as a skin sensitization agent under the IFRA standards and EU fragrance allergen framework. Multiple hazard statements (H317 skin sensitization, H319 eye irritation, H411 aquatic toxicity) reflect its profile. It is generally recognized as safe at low concentrations but requires careful formulation consideration.

Skin benefits

  • Provides pleasant vanilla fragrance to products
  • Antioxidant properties in formulations
  • Wide use in both cosmetics and food with established safety profile at low levels

Known concerns

  • H317 - may cause skin sensitization/allergic reaction
  • H319 - causes serious eye irritation
  • H411 - toxic to aquatic life with long-lasting effects
  • EU fragrance allergen declaration required above threshold
  • Environmental concern for aquatic toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.