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4-Nitro-1,2-phenylenediamine

CAS 99-56-9
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

4-nitro-1,2-phenylenediamine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

4-Nitro-1,2-phenylenediamine is a primary aromatic amine used as a coupling agent in oxidative hair dye formulations. It carries GHS hazard classifications for acute oral toxicity (H302) and skin sensitisation (H317), and is subject to EU restriction limits when used in hair dye contexts. The nitro group can be reduced to potentially carcinogenic aromatic amines in vivo, necessitating strict concentration controls and label declarations under EU cosmetic regulation.

Known concerns

  • Skin sensitiser (H317)
  • Acute oral toxicity (H302)
  • Potential metabolic reduction to carcinogenic aromatic amines
  • Aquatic toxicity concern

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.