Other
o-phenylenediamine dihydrochloride
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
O-phenylenediamine dihydrochloride is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
o-Phenylenediamine dihydrochloride (1,2-benzenediamine dihydrochloride) is a highly concerning aromatic amine salt. Multiple hazard statements include H350 (suspected of causing cancer), H341 (suspected of causing genetic defects), and H317 (may cause allergic skin reaction). It is subject to severe EU regulatory controls and restricted in cosmetic applications, particularly oxidative hair dye use where it can form carcinogenic oxidation products including benzimidazole and nitroaniline derivatives.
Known concerns
- EU regulated CMR substance (suspected)
- H350 carcinogenicity concern
- H341 mutagenicity concern
- Skin sensitizer
- Severe EU restrictions
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.