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4-NITRO-M-PHENYLENEDIAMINE SULFATE

CAS -
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-substituted aromatic diamine hair dye intermediate restricted under EU Regulation II/1282 due to mutagenicity and sensitization concerns.

4-Nitro-m-phenylenediamine sulfate is a nitro-aromatic hair dye intermediate regulated under EU Regulation 1223/2009 Annex II entry 1282. The nitro group substitution on the phenylenediamine structure significantly increases concerns around mutagenicity and phototoxicity compared to non-nitrated aromatic diamines. While it can produce vibrant color shades in oxidative hair dyeing, the compound is restricted to professional use only, with specific concentration limits. The sulfate salt form is used to improve solubility, but the underlying nitro-phenylenediamine structure remains a concern for skin sensitization and potential genotoxic effects.

Skin benefits

  • Hair dye intermediate for vivid color shades in professional oxidative formulations

Known concerns

  • EU Annex II/1282 restricted hair dye intermediate
  • Mutagenicity concerns from nitro substitution
  • Skin sensitization potential
  • Professional use only — not for consumer cosmetic products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.