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Skin Conditioning

ACORUS CALAMUS CALLUS EXTRACELLULAR VESICLES

45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Plant-callus vesicles from sweet flag (Acorus calamus). Concerning because the parent plant is a regulated source of beta-asarone, a genotoxic carcinogen.

Acorus calamus callus extracellular vesicles are nanoscale lipid vesicles isolated from plant cell cultures of Acorus calamus (sweet flag). The parent plant produces beta-asarone, an alkenylbenzene classified as genotoxic and carcinogenic; EU regulations restrict beta-asarone in food and flavourings, and EU CosIng restricts use of Acorus calamus oil unless beta-asarone is below specified limits. Whether callus-vesicle preparations carry residual asarones depends on the chemotype, callus protocol, and purification — disclosure is rarely transparent. There is no SCCS or CIR opinion on the vesicle ingredient.

Function

SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING, SKIN CONDITIONING - HUMECTANT, SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Plant-derived signalling vesicles
  • Vegan, sustainable callus source

Known concerns

  • Acorus calamus contains beta-asarone, a genotoxic carcinogen restricted in EU food and cosmetics
  • Composition of the vesicle preparation may carry parent-plant constituents
  • Novel ingredient with no SCCS or CIR opinion
  • Efficacy claims supplier-driven

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.