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ANDROGRAPHOLIDE

CAS 5508-58-7
80

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A diterpenoid lactone from the herb Andrographis paniculata with well-documented anti-inflammatory and antioxidant skin benefits.

Andrographolide is the principal bioactive diterpenoid from Andrographis paniculata, widely used in traditional medicine and increasingly in cosmetic formulations for its potent anti-inflammatory, antioxidant, and anti-aging properties. It is listed in CosIng and is a permitted cosmetic ingredient in the EU. While generally safe, andrographolide can be a moderate skin irritant at high concentrations and may cause allergic reactions in sensitive individuals. Its safety at cosmetic-use concentrations is well supported by available data.

Skin benefits

  • Potent anti-inflammatory activity
  • Antioxidant protection
  • Anti-aging and collagen-supporting properties
  • Antimicrobial benefits

Known concerns

  • May be a moderate skin irritant at high concentrations
  • Rare allergic/sensitization reactions possible
  • Safety at very high concentrations not fully established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.