Skip to content

Other

Arecoline

CAS 63-75-2
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Arecoline is a natural alkaloid from the betel nut with significant toxicity—it is a known mutagen, reproductive toxicant, and is banned in EU cosmetics at ≥0.1%.

Arecoline (CAS 63-75-2) is the primary alkaloid in Areca catechu (betel nut). It is classified as a Substances of Very High Concern (SVHC) under EU REACH due to reproductive toxicity (Repr. 1B; H361) and mutagenicity (Muta. 2; H341). EU cosmetics regulation prohibits its use in cosmetic mixtures at concentrations ≥0.1%. It acts as a cholinergic agonist with systemic effects. PubChem safety score: 3, reflecting severe toxicity concerns.

Known concerns

  • Reproductive toxicant (H361)
  • Mutagen (H341)
  • SVHC under REACH
  • Cholinergic agonist with systemic effects
  • EU ban in cosmetics at ≥0.1%

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

5
(Methyl-ONN-azoxy)methyl acetate
Other
 5
1-Chloro-2,3-epoxypropane (Epichlorohydrin)
Other
 5
3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride
Other
 5
5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO)
Other
 5
ACONITUM AUSTROKOREENSE FLOWER EXTRACT
Other
 5
AMMONIUM VANADATE
Other
 5
Acetorphine
Other
 5
Amphetamine sulphate [USP]
Other

Check your shelf

Find Arecoline in your products.

Scan any cosmetic product with LuxSense to see if it contains Arecoline and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.