Cosmetic preservative
Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-, and its salts (including isothionate and p-hydroxybenzoate)
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A diamidine antimicrobial preservative approved in the EU up to 0.1% under Annex VI of the Cosmetics Regulation. Effective at low levels, with some risk of skin contact sensitization in susceptible users.
Skin benefits
- Antimicrobial preservative effective against bacteria and yeast
- Permitted in EU cosmetics at up to 0.1% (Annex VI, V/E 33)
- Long history of cosmetic preservation use
Known concerns
- GHS H302 harmful if swallowed
- Can cause contact dermatitis and sensitization
- Quaternary ammonium-class allergen for some users
- Restricted maximum concentration in EU cosmetics
- Antimicrobial use can disturb skin microbiome
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.