Skin Conditioning
CALCIUM HYDROXYMETHYLBUTYRATE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
The calcium salt of HMB (a leucine metabolite). Well-known in sports nutrition — being explored for topical conditioning use.
Calcium hydroxymethylbutyrate (CAS 135236-72-5, commonly calcium HMB) is the calcium salt of beta-hydroxy beta-methylbutyrate, a metabolite of the amino acid leucine. It has a long nutritional/sports-supplement safety record at oral doses of a few grams daily. Cosmetic use is newer — proposed as a skin-conditioning agent, potentially supporting protein metabolism locally. Topical cosmetic efficacy data is limited and largely supplier-led (low evidence). Class safety is strong. No EU Annex II/III restriction; no GHS hazard.
Function
Skin benefits
- Mild skin conditioning
- Amino-acid-metabolite heritage
- Compatible with sensitive skin
Known concerns
- Limited topical efficacy data
- Supplier-led evidence
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.