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Cephaeline and its salts

CAS 483-17-0
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cephaeline And Its Salts is a cosmetic ingredient. Raw material has significant toxicity. Exercise caution due to limited available safety data.

Cephaeline is an isoquinoline alkaloid from Carapichea ipecacuanha (ipecac root) with potent emetic properties. It acts centrally via the chemoreceptor trigger zone and directly on the GI tract. EU CLP classification includes H300 (fatal if swallowed) and H330 (fatal if inhaled). The emetic effect at low doses and potential for systemic toxicity (particularly in children) led to its prohibition in cosmetic products. The EU Cosmetics Regulation Annex II prohibits cephaeline and its salts.

Known concerns

  • Acute toxicity H300/H330
  • Potent emetic agent
  • Toxic isoquinoline alkaloid
  • Risk to children
  • Banned in EU cosmetics (Annex II)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.