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Cyclophosphamide (INN) and its salts

CAS 50-18-0
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cyclophosphamide (INN) and its salts is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Cyclophosphamide (INN) and its salts (CAS 50-18-0) is a chemotherapeutic alkylating agent classified as a Category 1B CMR (Carcinogen, Mutagen, Reprotoxic) substance under EU CLP regulation. It carries multiple hazard statements including H301/H302 (acute toxicity), H318 (serious eye damage), H340 (genotoxicity), H350 (carcinogenicity), H360 (reprotoxicity), H362 (reproductive toxicity), H370 (specific organ toxicity), and H372 (target organ toxicity). It is listed on EU Annex II (prohibited substances) for cosmetic use.

Known concerns

  • EU Annex II prohibited substance
  • CMR Category 1B substance
  • Carcinogen (H350)
  • Genotoxic (H340)
  • Reprotoxic (H360, H362)
  • Acute toxicity (H301, H302)
  • Multiple organ toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.