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DEQUALINIUM ACETATE

CAS 4028-98-2
50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dequalinium Acetate is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Dequalinium Acetate is a quaternary ammonium compound (quat) with broad-spectrum antimicrobial activity used as a preservative in cosmetic formulations. While effective against bacteria and fungi, quaternary ammonium compounds can cause skin and eye irritation, particularly with prolonged or repeated exposure. Some quats have been associated with contact dermatitis, and their environmental toxicity (particularly to aquatic organisms) is a recognised concern. The acetate counterion moderates the compound's irritability somewhat. EU restrictions on quaternary ammonium compounds in leave-on and eye area products apply.

Skin benefits

  • Antimicrobial preservative activity
  • Broad-spectrum activity against bacteria and fungi

Known concerns

  • Skin and eye irritation potential
  • Contact dermatitis concern in sensitised individuals
  • Environmental toxicity — aquatic hazard
  • Restriction in leave-on and eye area products under EU regulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.