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desomorphine

CAS 427-00-9
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Desomorphine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Desomorphine (also known as 'krokodil') is a synthetic morphine derivative with approximately 10x the potency of morphine. It causes severe respiratory depression, addiction, and extensive tissue damage including gangrene and necrosis at injection sites. It has no cosmetic, pharmaceutical, or any legitimate commercial application. As a Schedule I controlled substance and a substance of grave concern for human health, it is prohibited in all cosmetic products under EU Cosmetics Regulation Annex II. Any incidental presence is unacceptable in any cosmetic formulation.

Known concerns

  • Highly addictive opioid agonist
  • Severe respiratory depression
  • Extensive tissue necrosis (gangrene)
  • Schedule I controlled substance
  • EU Annex II banned - zero tolerance in cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.