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DIHYDRONIACINAMIDE RIBOSIDE ACETYL TRI-T-BUTYL TRYPTOPHANATE

85

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A multi-component vitamin B3 (niacinamide) and tryptophan derivative designed for enhanced skin delivery and stability, with a favourable safety profile expected from its well-tolerated parent compounds.

This is a complex molecular conjugate combining dihydronicotinamide (a reduced form of niacinamide/vitamin B3) with a t-butyl-protected tryptophan moiety via an acetyl linker. Niacinamide itself is extensively studied, well-tolerated in cosmetics, and listed in EU CosIng without restrictions. The t-butyl tryptophan fragment is a protected amino acid derivative — the t-butyl ester and amide protections are chemically stable under cosmetic use conditions and are fragments of widely-used pharmaceutical protecting groups with no intrinsic toxicity. The overall conjugate is expected to have an excellent safety profile consistent with its vitamin B3 heritage.

Skin benefits

  • Enhanced skin delivery of niacinamide via conjugate design
  • Potential antioxidant and anti-aging benefits from both B3 and tryptophan fragments
  • Stable protected form unlikely to cause flushing

Known concerns

  • Complex novel conjugate — limited specific in vivo safety data
  • No EU CosIng specific restriction entries identified
  • Broadly regarded as safe based on parent compound toxicology

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.