Other
DODOXYNOL-13
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Dodoxynol-13 is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
DODOXYNOL-13 is a nonionic surfactant derived from a tributyl-substituted phenyl group condensed with approximately 13 moles of ethylene oxide. Alkylphenol ethoxylates like this one are subject to EU REACH restrictions due to the environmental hazard profile of their degradation products. While the parent compound is not listed in EU Annex II, formulators must ensure their supplier's technical grade meets quality standards for residual monomers and that a safety assessment covers use in leave-on products. The 13 EO degree provides moderate water solubility and a relatively balanced irritation profile.
Skin benefits
- Effective emulsifier for a range of oil phases including more challenging hydrophobic ingredients
- Provides good solvency and dissolution properties
Known concerns
- EU REACH environmental hazard classification applies to alkylphenol ethoxylate class
- Potential for metabolite environmental persistence requires responsible formulation choices
- Moderate EO degree may produce mild skin irritation in some individuals
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.