(E)-3-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

About (E)-3-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

A cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

This compound is a structural analog of tamoxifen featuring a dimethylaminoethoxy phenyl group and a triphenylethylene SERM scaffold. It is classified under EU CLP (EC 1272/2008) with Danger signal word and multiple hazard statements: H317 (skin sensitizer), H351 (carcinogen suspected), H360F (reproductive toxicity), H400 (acute aquatic hazard), and H410 (chronic aquatic hazard). The triphenylethylene SERM pharmacophore is a recognized endocrine disruptor with documented reproductive and developmental toxicity. It is listed in EU Annex II (prohibited substances) of the Cosmetics Regulation, meaning it cannot be used in cosmetic products at any concentration. Its intended pharmacological activity as a SERM is incompatible with cosmetic use.

Known Concerns

• ⚠ EU Annex II prohibited substance — absolute ban in cosmetics regardless of concentration
• ⚠ CMR 1B classified under EU CLP Regulation (H360F reproductive toxicity, H351 carcinogenicity)
• ⚠ H317 skin sensitizer; H400/H410 environmental hazard
• ⚠ Tamoxifen-like SERM activity — endocrine disruption mechanism of action

References