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GLYCYRRHIZA URALENSIS ROOT EXTRACELLULAR VESICLES

79

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Nanocarrier vesicles from licorice root cell cultures carrying glycyrrhizin and flavonoids that soothe inflammation and brighten the skin.

Glycyrrhiza Uralensis Root Extracellular Vesicles are secreted by cultured root cells into the growth medium. These EVs encapsulate glycyrrhizin, liquiritin, isoliquiritigenin, and various flavonoids characteristic of licorice root. The vesicular structure enhances dermal delivery of these anti-inflammatory compounds. Glycyrrhizin modulates the HPA axis pathway and inhibits 5-lipoxygenase. Liquiritin is a known tyrosinase inhibitor for hyperpigmentation reduction.

Skin benefits

  • Anti-inflammatory
  • Brightening
  • Antioxidant
  • Soothing

Known concerns

  • Glycyrrhizin may affect cortisol metabolism at very high systemic doses (topical use poses minimal risk at normal cosmetic concentrations)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.