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HESPERETIN

CAS 520-33-2
85

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Hesperetin is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Hesperetin is a flavanone (a subclass of flavonoid) predominantly found in citrus fruits, especially oranges and lemons. It exhibits strong antioxidant activity, anti-inflammatory effects, and vasoprotective properties. Hesperetin and its glycoside form hesperidin are permitted cosmetic ingredients under EU Regulation 1223/2009 with no specific restriction. Naturally derived hesperetin is considered safe with a low incidence of adverse effects, though synthetic or highly concentrated forms warrant purity evaluation.

Skin benefits

  • Antioxidant protection from free radical damage
  • Anti-inflammatory skin calming
  • Supports skin elasticity and collagen
  • May help reduce capillary permeability

Known concerns

  • Generally well-tolerated; minimal concerns
  • Source and purity should be verified for synthetic forms

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.