Conditioning Agent
HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A recombinant fusion peptide combining two growth-factor-like sequences, intended to support skin regeneration and repair.
This recombinant fusion peptide joins Hexapeptide-40 with sh-Oligopeptide-1 (a synthetic analogue of human growth factor), produced via E. coli fermentation. The ingredient consists entirely of standard amino acids in a defined sequence. EU cosmetic regulation classifies recombinant peptides under Annex II entry 416 without specific concentration limits, reflecting general safety at cosmetic use levels. The absence of post-translational modifications typical of human growth factors reduces but does not eliminate the potential for unexpected biological activity.
Function
Skin benefits
- May promote fibroblast proliferation and skin renewal
- Potential improvement in skin texture and firmness
Known concerns
- Growth-factor-like activity warrants caution in sensitive skin types
- E. coli expression may introduce trace endotoxin contaminants
- Limited independent safety data for this specific fusion sequence
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.