Skin Conditioning
HEXAPEPTIDE-55 PALMITATE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A palmitoylated signal peptide used as a skin-conditioning active. Typical use is at parts-per-million levels where irritation risk is minimal.
Hexapeptide-55 palmitate is a synthetic six-amino-acid peptide conjugated to palmitic acid to help it cross the stratum corneum. It is marketed as an anti-aging signal peptide. The CIR has reviewed related palmitoyl oligopeptides (e.g., palmitoyl tripeptide-1, palmitoyl hexapeptide-12) and concluded them safe at current cosmetic use patterns (typical 0.0001-0.01%). Hexapeptide-55 palmitate itself has no dedicated CIR or SCCS opinion, and no GHS classification is available. The palmitate family lacks nitrosamine-forming amines and is not sensitizing at realistic levels. Evidence for efficacy claims is proprietary; evidence for safety is by class analogy.
Function
Skin benefits
- Skin conditioning signal peptide
- Used at very low concentrations
- Low irritation potential
Known concerns
- Limited public safety data for this specific peptide
- Efficacy claims exceed independent evidence
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.