Conditioning Agent
HUMAN CORONAVIRUS OLIGOPEPTIDE-1 SP
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A 36-amino-acid synthetic peptide based on the spike glycoprotein of Human Coronavirus 229E, listed with EU restriction II/416, used for skin protecting benefits.
Human Coronavirus Oligopeptide-1 SP is a 36-amino-acid synthetic peptide based on the spike glycoprotein of the pathogenic Human Coronavirus 229E strain. Despite the viral origin of the sequence, the peptide is fully synthetic and does not contain any live or inactivated viral material. The EU CosIng database lists a restriction reference II/416 for this ingredient, indicating it has been subject to specific safety assessment by the EU Scientific Committee on Consumer Safety (SCCS). Restriction II/416 typically refers to allergens or substances requiring specific purity criteria.
Function
Skin benefits
- Skin protecting function through spike glycoprotein-derived peptide
- Synthetic production ensures no infectious material is present
- May support barrier-related skin protecting claims
Known concerns
- EU CosIng restriction II/416 indicates specific SCCS conditions must be met
- Viral origin of the sequence requires rigorous purity assessment to confirm no biological activity
- Consumer perception concerns may arise from 'coronavirus' in the INCI name
- Must comply with any SCCS opinion or conditions attached to restriction II/416
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.