Enzyme
HYALURONIDASE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An enzyme that breaks down hyaluronic acid. Limited use in topical cosmetics; mainly used medically to dissolve HA fillers, with allergic-reaction and tissue-degradation concerns.
Function
Skin benefits
- Used to depolymerize hyaluronic acid in topical products
- Increases tissue permeability when used medically
- Can theoretically support penetration enhancement
Known concerns
- Enzymatic protein — potential for allergic reactions
- Active enzyme can degrade endogenous hyaluronic acid in skin
- Used medically to dissolve HA fillers — vascular risk in injectable contexts
- Less suitable for general consumer cosmetics
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related enzymes
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.