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Enzyme

HYALURONIDASE

CAS 37326-33-3
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An enzyme that breaks down hyaluronic acid. Limited use in topical cosmetics; mainly used medically to dissolve HA fillers, with allergic-reaction and tissue-degradation concerns.

Function

SKIN CONDITIONING

Skin benefits

  • Used to depolymerize hyaluronic acid in topical products
  • Increases tissue permeability when used medically
  • Can theoretically support penetration enhancement

Known concerns

  • Enzymatic protein — potential for allergic reactions
  • Active enzyme can degrade endogenous hyaluronic acid in skin
  • Used medically to dissolve HA fillers — vascular risk in injectable contexts
  • Less suitable for general consumer cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related enzymes

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SERRALYSIN
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ALKALINE PHOSPHATASE
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OXIDO REDUCTASES
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.