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SERRALYSIN

CAS 37312-62-2
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A protease enzyme produced by Serratia marcescens bacteria, used in cosmetics but raising concerns due to its microbial origin.

Serralysin (CAS 37312-62-2) is a metalloprotease enzyme produced by Serratia marcescens, a gram-negative bacterium. The source organism raises concerns as Serratia marcescens is an opportunistic pathogen and can produce bioactive secondary metabolites. The EU Cosmetics Regulation requires strict controls on enzyme preparations, particularly those from bacterial sources. Allergenic potential exists from residual bacterial proteins and endotoxins. The SCCS has noted concerns about bacterial enzyme preparations in cosmetics. Purification is critical to remove bacterial contaminants, and enzyme activity must be controlled to prevent skin over-exfoliation.

Skin benefits

  • Proteolytic enzymatic activity
  • May provide gentle exfoliation at controlled levels

Known concerns

  • Bacterial origin (Serratia marcescens) raises pathogen concerns
  • Potential endotoxin contamination
  • Skin sensitization and irritation risk
  • Requires extensive purification

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.