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HYDROXYETHYL-2-NITRO-P-TOLUIDINE

CAS 100418-33-5
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-substituted toluidine hair dye intermediate restricted in the EU under Annex III, carrying significant sensitization risk.

Hydroxyethyl-2-nitro-p-toluidine is a nitro-substituted aromatic hair dye intermediate regulated under EU Annex III reference III/221, placing it in the category of substances permitted only under the restrictions specified. Nitro-substituted toluidines are structurally related to compounds the SCCS has identified as requiring particular attention due to potential for aromatic amine release during hair dyeing processes. This hydroxyethyl derivative modifies the lipophilicity and may alter penetration characteristics compared to parent nitro-toluidine compounds.

Skin benefits

  • Provides golden to orange tones in combination hair dye formulations
  • Acts as a primary intermediate in oxidative coloring systems

Known concerns

  • EU Annex III restricted (III/221) with specific use conditions
  • Structural alerts for potential carcinogenic aromatic amine release
  • Nitro group reduction may occur in skin or hair follicle environment
  • SCCS has flagged nitro-toluidine derivatives for careful risk assessment

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.