Exfoliant
KALLIKREIN
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A serine protease enzyme (CAS 9001-01-8). Biologically active — useful for exfoliation but raises barrier/irritation concerns if misused.
Kallikrein (CAS 9001-01-8) is a family of serine proteases; in skin biology kallikreins 5 and 7 regulate desquamation, and their overactivity is implicated in Netherton syndrome and atopic dermatitis. As a cosmetic ingredient, applied kallikrein is marketed for gentle enzymatic turnover. Because active proteases can disrupt barrier proteins (corneodesmosomes), misformulation or elevated activity carries a real risk of stinging, redness and impaired barrier function. Historically sourced from porcine pancreas; recombinant and synthetic versions exist. No specific EU restriction, but kallikrein-type proteases are treated cautiously by CIR and formulators.
Function
Skin benefits
- Serine protease that helps with gentle exfoliation
- Used in specialty peeling/turnover products
- Localised activity only
Known concerns
- Proteolytic enzyme — irritation and barrier-damage risk
- Animal/human origin complications
- Kallikrein-family overactivity linked to skin disease (Netherton syndrome)
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related exfoliants
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.