KERATINASE

Other

55

Moderate

CAS Number: 9025-41-6

About KERATINASE

A proteolytic enzyme that degrades keratin, used in cosmetics for exfoliation and hair softening, but with potential skin irritation concerns.

Detailed Analysis

Keratinase is a proteolytic enzyme produced by various microorganisms that catalyses keratin hydrolysis. Not specifically restricted in EU Regulation 1223/2009, but as a proteolytic enzyme it carries inherent sensitisation potential. The EU SCCS has noted concerns about enzyme-based cosmetic ingredients regarding skin and respiratory sensitisation. Concentration should be controlled and appropriate preservation is essential.

Skin Benefits

  • Exfoliation
  • Hair softening and conditioning
  • Keratin breakdown for smoother skin texture

Known Concerns

  • Proteolytic activity can cause skin irritation and sensitisation
  • EU SCCS has flagged enzymatic ingredients for potential respiratory and skin sensitisation concerns

Safety Score

55

Moderate

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.