Other
KOJIC ISOPALMITATE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A kojic acid derivative used as a skin-lightening agent that addresses the stability concerns of free kojic acid while maintaining tyrosinase-inhibiting activity.
Kojic isopalmitate is an esterified derivative of kojic acid, designed to improve the stability and skin penetration of the parent compound. Kojic acid itself is a naturally derived tyrosinase inhibitor used for skin brightening but has stability and sensitization concerns; esterification mitigates some of these. CosIng lists this derivative without specific restriction under Annexes I–III. The isopalmitate ester has better lipid solubility, improving delivery. While kojic acid has been reviewed for safety, the derivative form has a more favorable profile with lower direct irritation potential.
Skin benefits
- Tyrosinase inhibition for skin brightening and hyperpigmentation reduction
- Antioxidant properties protect against post-inflammatory hyperpigmentation
- Improved lipid solubility enhances skin penetration compared to free kojic acid
- Used for evening skin tone and reducing age spots
Known concerns
- Mild skin sensitization potential in individuals with sensitivity to kojic acid
- Use in leave-on products should follow SCCS guidance on concentration limits for kojic acid derivatives
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.