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megestrol acetate (USAN)

CAS 595-33-5
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Megestrol Acetate (usan) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Megestrol acetate (CAS 595-33-5) is a synthetic derivative of progesterone with predominantly progestogenic activity, used in human medicine for appetite stimulation and cancer treatment. EU Regulation 1223/2009 Annex II classifies this substance as a prohibited cosmetic ingredient due to its steroidal hormonal activity. Its use in cosmetic products would present unacceptable endocrine disruption risk, and it is not listed in EU CosIng for any cosmetic function.

Known concerns

  • EU Annex II banned — synthetic progestogen
  • Pharmaceutical drug substance not suitable for cosmetics
  • Endocrine disruption risk

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.