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Metyrapone (INN)

CAS 54-36-4
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Metyrapone (inn) is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Metyrapone is a pharmaceutical agent that inhibits 11β-hydroxylase and blocks cortisol synthesis, used in the diagnosis and treatment of Cushing's syndrome. It is listed in EU Regulation (EC) No 1223/2009 Annex II (prohibited substances) as a pharmaceutical with no cosmetic application. The ingredient has pharmacological activity incompatible with the safety objectives of cosmetic regulation and is not listed in CosIng as a permitted cosmetic ingredient.

Known concerns

  • Pharmaceutical agent — prohibited in cosmetics (EU Annex II)
  • Pharmacological activity incompatible with cosmetic safety
  • No safety assessment for cosmetic exposure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.