Morpholine, phosphate (3:1)
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A morpholine phosphate salt used as an anti-static agent or chemical intermediate in cosmetic formulations. Morpholine itself can form nitrosamines with nitrosating agents, requiring careful formulation to avoid this reaction.
Morpholine, phosphate (3:1) is a salt of morpholine (a secondary amine heterocycle) with phosphoric acid. Under EU REACH regulation, morpholine requires classification for specific health effects, though it is not listed in EU Annex II (banned substances) of the Cosmetics Regulation. The key concern with morpholine and its salts is nitrosamine formation: morpholine can react with nitrosating agents (e.g., nitrite preservatives, atmospheric NOx) to form N-nitrosomorpholine, a suspected carcinogen. Formulators must avoid combining morpholine-containing ingredients with nitrosating species.
Known concerns
- Morpholine component can form N-nitrosomorpholine (suspected carcinogen) with nitrosating agents
- Formulation interactions must be carefully controlled
- Secondary amine reactivity
- Limited cosmetics-specific safety data
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Check your shelf
Find Morpholine, phosphate (3:1) in your products.
Scan any cosmetic product with LuxSense to see if it contains Morpholine, phosphate (3:1) and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.