Conditioning Agent
NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-86
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A fusion peptide produced in transgenic tobacco plants containing Follistatin-derived sequences, offering a novel expression system but with less safety history than bacterial or yeast production.
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-86 (CAS 117628-82-7) is a fusion peptide of 294 amino acids produced by transient expression in transgenic Nicotiana benthamiana plants. The plant expression system allows for eukaryotic protein folding and post-translational modifications, but introduces uncertainty around glycosylation patterns and potential plant-specific contaminants. The EU SCCS has not issued specific guidance on this ingredient, which falls under the broader category of recombinant peptides.
Function
Skin benefits
- Hair conditioning function
- Recombinant Follistatin-derived sequence may influence muscle tone aesthetics
Known concerns
- Plant expression system introduces variable glycosylation
- Limited human safety data compared to bacterial or yeast expression systems
- Potential for plant-derived impurities
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.