Skin Conditioning
NICOTINOYL HEXAPEPTIDE-44
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Nicotinoyl Hexapeptide-44 — a niacin-tagged hexapeptide. Plausible, low-exposure; evidence is supplier-driven.
Nicotinoyl Hexapeptide-44 is a synthetic six-amino-acid peptide with a nicotinoyl (niacin, vitamin B3) group, marketed for anti-ageing and skin-signalling claims. Listed in EU CosIng; no SCCS opinion. Use levels are in the parts-per-million range. Public safety and efficacy literature is limited; evidence comes largely from supplier in-vitro and small in-vivo dossiers. Niacin moieties can transiently flush at high topical concentration, but typical use is far below that. Evidence level low.
Function
Skin benefits
- Peptide-niacin hybrid
- Low-use-level exposure
- Short-term tolerance
Known concerns
- Thin public safety data
- No SCCS dossier
- Proprietary evidence
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
Check your shelf
Find NICOTINOYL HEXAPEPTIDE-44 in your products.
Scan any cosmetic product with LuxSense to see if it contains NICOTINOYL HEXAPEPTIDE-44 and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.