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Skin Conditioning

NICOTINOYL HEXAPEPTIDE-44

68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Nicotinoyl Hexapeptide-44 — a niacin-tagged hexapeptide. Plausible, low-exposure; evidence is supplier-driven.

Nicotinoyl Hexapeptide-44 is a synthetic six-amino-acid peptide with a nicotinoyl (niacin, vitamin B3) group, marketed for anti-ageing and skin-signalling claims. Listed in EU CosIng; no SCCS opinion. Use levels are in the parts-per-million range. Public safety and efficacy literature is limited; evidence comes largely from supplier in-vitro and small in-vivo dossiers. Niacin moieties can transiently flush at high topical concentration, but typical use is far below that. Evidence level low.

Function

ANTIOXIDANT, SKIN PROTECTING

Skin benefits

  • Peptide-niacin hybrid
  • Low-use-level exposure
  • Short-term tolerance

Known concerns

  • Thin public safety data
  • No SCCS dossier
  • Proprietary evidence

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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NICOTINOYL HEXAPEPTIDE-45
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.