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NONYL NONOXYNOL-8 PHOSPHATE

CAS 39464-64-7
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Nonyl Nonoxynol-8 Phosphate is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Nonyl Nonoxynol-8 Phosphate is a dinonylphenyl ethoxylate (8 mol EO average) converted to its phosphate ester. Unlike the -7 analogue, no GHS hazard statements are listed for this specific variant. However, it shares the same structural class as Nonyl Nonoxynol-7 Phosphate, and the nonylphenol ethoxylate backbone remains a concern under EU REACH due to endocrine-disrupting potential of nonylphenol and related degradation products. The phosphate group adds surfactant-mediated skin and eye irritation risk. EU Annex III restrictions on related alkylphenol ethoxylates may apply by extension. Use in leave-on cosmetics warrants caution.

Skin benefits

  • Effective surfactant and emulsifier

Known concerns

  • Endocrine-disrupting potential of nonylphenol backbone (EU REACH concern)
  • Skin and eye irritation from phosphate surfactant activity
  • Structural analog to regulated alkylphenol ethoxylates

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.