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norgestrienone

CAS 848-21-5
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Norgestrienone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Norgestrienone (CAS 848-21-5) is a 19-nor synthetic steroid with strong progestogenic and anabolic activity, structurally related to other 19-nortestosterone derivatives. Its listing in EU Annex II of Regulation 1223/2009 reflects a general prohibition on hormonal anabolic steroids in cosmetic products. No safe use level or cosmetic function has been established, and its potency as a progestogen raises serious concerns about systemic hormonal effects from even trace topical absorption.

Known concerns

  • EU Annex II banned — potent anabolic progestogen
  • Endocrine disruption from topical exposure
  • No safe cosmetic use threshold established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.