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OCTOXYNOL-33

CAS 9002-93-1
62

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Octoxynol-33 is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Octoxynol-33 with 33 ethylene oxide units represents the gentler end of the octoxynol spectrum—longer EO chains reduce irritation potential and improve water solubility. However, the underlying 4-tert-octylphenol structure remains unchanged and is the root of EU regulatory concern. Higher-EO octoxynols degrade to longer-chain ethoxylates and ultimately octylphenol. The SCCS has not issued a specific opinion on octoxynols, placing them in a gray area: not banned, but under ongoing environmental risk assessment scrutiny in the EU.

Known concerns

  • Environmental concern: ultimate degradation product is endocrine-disrupting octylphenol
  • Generally lower irritation than short-chain variants but not inert
  • No specific EU cosmetic restriction, but subject to REACH environmental evaluation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.