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Skin Conditioning

OLIGOPEPTIDE-177 TRIFLUOROACETATE

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A short synthetic peptide supplied as the trifluoroacetate salt. The peptide itself is plausibly mild, but TFA is a persistent fluorinated by-product.

Oligopeptide-177 Trifluoroacetate is a short synthetic peptide isolated from solid-phase peptide synthesis as its trifluoroacetate (TFA) salt. The peptide itself is supplied at parts-per-million levels for skin-conditioning use; intact skin penetration is negligible and irritation potential is low. The flag is the counterion: trifluoroacetic acid is a persistent fluorinated organic acid that does not break down in the environment and is increasingly recognised alongside the broader PFAS family as a contaminant of concern. Modern peptide-cosmetic suppliers increasingly offer TFA-free (acetate-exchanged) grades for this reason. There is no CIR or SCCS opinion specific to this peptide. Independent efficacy data is sparse.

Function

SKIN PROTECTING

Skin benefits

  • Skin conditioning
  • Marketed signaling support
  • Low irritation at use levels

Known concerns

  • TFA counterion is environmentally persistent
  • No regulatory monograph
  • Sparse independent data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.