Conditioning Agent
OLIGOPEPTIDE-222 AMIDE
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A 15-residue synthetic peptide with an amidated C-terminus that enhances stability, used for skin conditioning with a favourable safety profile.
Oligopeptide-222 Amide is a synthetic peptide containing four standard amino acids (arginine, lysine, tryptophan and valine) across 15 residues, with an amidated C-terminus that increases resistance to enzymatic degradation. The amide capping is a common strategy to improve peptide stability in topical formulations. It is not restricted under EU cosmetics law and is used in skin conditioning applications.
Function
Skin benefits
- Enhanced stability in formulation due to C-terminal amide
- Skin conditioning function
Known concerns
- Limited independent safety studies
- Tryptophan content may contribute to rare photosensitisation
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.